Injuries, per usual, are having an impact on these rankings. Marlon Mack is the most notable name who is likely to miss time after suffering an apparent season-ending Achilles’ injury. With Mack out, Jonathan Taylor will likely be the Colts’ lead-back, so he’s a must-play upside against a Vikings defense that just got torn apart by the Packers. Additionally, the aforementioned Hines is on the rise because Philip Rivers seems to like throwing to him in an Austin Ekeler-type capacity. That will make him a good flex in standard and a potential RB2 in PPR leagues.

WEEK 2 STANDARD RANKINGS:Quarterback | Wide receiver | Tight end | D/ST | Kicker

There are some other injuries that could have an impact here. Le’Veon Bell’s hamstring will be the one to watch this week, along with the hamstring of Miles Sanders. If Sanders can’t go, the health of Boston Scott, who left Sunday’s game with an injury of his own, will be crucial. If both Sanders and Scott are out, Corey Clement could be the lead back for the Eagles against the Rams. (UPDATE:  Bell will not play this week, leaving Frank Gore and either La’Mical Perine or Kalen Ballage as the Jets primary ball-carriers against San Francisco. Sanders and Scott will both play.)

WEEK 2 PPR RANKINGS:Quarterback | Running back | Wide receiver | Tight end |  D/ST | Kicker

Despite those injuries, most of the league’s best backs made it through Week 1 unscathed and remain toward the top of this week’s rankings. Some are elevated in better matchups than usual, including Derrick Henry (vs. Jaguars) and Aaron Jones (vs. Lions). If you have a stud at the RB position, don’t get cute and sit them even in a bad matchup. The position is too thin to do that.

WEEK 2 NFL DFS CASH LINEUPS:Yahoo | DraftKings | FanDuel

Right now, it’s too early to recommend fading any RB2s in poor matchups. It’s only Week 2, and there aren’t a ton of guys that you can rely on to be better than the top-25 backs. Just roll with the best players and keep them in your lineup until there’s a larger sample size from which to make informed lineup decisions.

WEEK 2 NFL DFS TOURNAMENT LINEUPS:Yahoo | DraftKings | FanDuel

Reminder: As always, we expect to make plenty of changes to these RB rankings throughout the week, so check back for updates and individual player analysis. 

WEEK 2 DFS: Best stacks | Best values | Lineup Builder

Week 2 Fantasy RB Rankings (Standard)

These rankings are for non-PPR leagues.